ChM Dr. Syahrul Imran Abu Bakar

2026

Therapeutic potential of Ni(II), Pd(II), and Pt(II) coumarin Schiff base complexes for acetylcholinesterase and butyrylcholinesterase inhibition

Journal of Molecular Structure · 1354 · ISSN 00222860

1 citation

2026

Theoretical investigation of selective inhibitory activity of chromone-based compounds against monoamine oxidase (MAO)-A and -B

Journal of Biomolecular Structure and Dynamics · 44(5) · ISSN 07391102

2 citations

2025

Design, Synthesis, and Computational Studies of Novel N-(Substituted phenyl)-3-(5-((naphthalen-2-yloxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetamides as Potent Acetylcholinesterase Inhibitors

ACS Omega · 10(39) · ISSN 24701343

1 citation

2025

Natural chromones targeting autophagy signalling pathways as potential anticancer interventions: a systematic review

Results in Chemistry · 17 · ISSN 22117156

1 citation

2025

Synthesis and In Vitro Evaluation of Triazole-Based N-(Substituted phenyl)-5-[(benzyl)-4-(phenyl)-4H-1,2,4-triazol-3-ylthio]acetamides as Potent Acetylcholinesterase Inhibitors

ChemistrySelect · 10(16) · ISSN 23656549

1 citation

2025

Identification of new structure of indol-3-acetyl-arylsulfonohydrazide as potent α-glucosidase and α-amylase inhibitors and molecular docking

Journal of Molecular Structure · 1323 · ISSN 00222860

2 citations

2025

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors

Journal of Molecular Structure · 1321 · ISSN 00222860

1 citation

2025

Chemical Profile, Physicochemical Properties and Antioxidant Activity of Malaysian Propolis: Insights from Honeybee and Stingless Bee

Journal of Science and Mathematics Letters · 13(1) · ISSN 24622052

5 citations

2025

Synthesis and biological evaluation of novel coumarin derivatives bearing sulfonamide moiety as potent α-glucosidase inhibitors

Journal of the Iranian Chemical Society · 22(1) · ISSN 1735207X

2 citations

2024

Molecular networking-based mass spectral identification of Brucea javanica (L.) Merr. metabolites and their selective binding affinities for dengue virus enzymes

Fitoterapia · 175 · ISSN 0367326X

4 citations

2024

New piperidinyl heterocyclic azoles acquired through Li(I)-catalyzed reactions: Anti-enzymatic, ADME and computational studies

Journal of Molecular Structure · 1302 · ISSN 00222860

5 citations

2024

Styryllactones in the leaves of Goniothalamus lanceolatus Miq., molecular networking and their anti-dengue activity In vitro and In silico

Phytochemistry Letters · 60 · ISSN 18743900

1 citation

2024

Synthesis of benzimidazole derivatives and their antiglycation, antioxidant, antiurease and molecular docking study

Arabian Journal of Chemistry · 17(4) · ISSN 18785352

8 citations

2024

The role of commonly used transition metals in total synthesis of indole alkaloids

Arabian Journal of Chemistry · 17(2) · ISSN 18785352

2 citations

2024

Nanoemulsion of Ethanolic Extract of Centella asiatica (NanoSECA) Ameliorates Learning and Memory Performance by Enhancing Cholinergic Activities, Increasing Antioxidative Levels, and Attenuating Oxidative Stress Markers in Adult Rats

Pharmaceutical Nanotechnology · 12(4) · ISSN 22117385

1 citation

2024

Goniothalamin and Its Analogues as Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme: Molecular Docking, Molecular Dynamics Simulation Studies, and Pharmacokinetics Analysis

Malaysian Journal of Chemistry · 26(1) · ISSN 15112292

1 citation

2024

New Quinoline Analogues: As Potential Diabetics Inhibitors and Molecular Docking Study

Polycyclic Aromatic Compounds · 44(1) · ISSN 10406638

7 citations

2023

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study

Arabian Journal of Chemistry · 16(12) · ISSN 18785352

4 citations

2023

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase

Journal of Molecular Structure · 1282 · ISSN 00222860

16 citations

2023

In vitro and in silico assessment of bioactivity properties and pharmacokinetic studies of new 3,5-disubstituted-1,2,4-triazoles

Journal of Molecular Structure · 1275 · ISSN 00222860

9 citations

2023

New pyrrolopyridine-based thiazolotriazoles as diabetics inhibitors: enzymatic kinetics and in silico study

Future Medicinal Chemistry · 15(5) · ISSN 17568919

2 citations

2023

Discovering biological efficacy of new thiadiazole as effective inhibitors of urease, glycation, and (DPPH) scavengers: Biochemical and in silico study

Journal of Molecular Structure · 1274 · ISSN 00222860

3 citations

2023

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line

Pharmaceuticals · 16(2) · ISSN 14248247

22 citations

2023

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies

Computational Toxicology · 25 · ISSN 24681113

11 citations

2023

Virtual screening of bioactive anti-SARS-CoV natural products and identification of 3β,12-diacetoxyabieta-6,8,11,13-tetraene as a potential inhibitor of SARS-CoV-2 virus and its infection related pathways by MD simulation and network pharmacology

Journal of Biomolecular Structure and Dynamics · 41(23) · ISSN 07391102

1 citation

2023

Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation

Journal of Biomolecular Structure and Dynamics · 41(23) · ISSN 07391102

12 citations

2023

Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles

Journal of Biomolecular Structure and Dynamics · 41(22) · ISSN 07391102

5 citations

2022

Synthesis of ruthenium complexes and their catalytic applications: A review

Arabian Journal of Chemistry · 15(11) · ISSN 18785352

74 citations

2022

Computational Screening of Styryl Lactone Compounds Isolated from Goniothalamus Species to Identify Potential Inhibitors for Dengue Virus

Journal of Computational Biophysics and Chemistry · 21(7) · ISSN 27374165

4 citations

2022

Synthesis and Molecular Docking of New Bis-Thiazolidinone-Based Chalcone Analogs as Effective Inhibitors of Acetylcholinesterase and Butyrylcholinesterase

Chemistry and Biodiversity · 19(10) · ISSN 16121872

9 citations

2022

(R)-13aα-Densiindolizidine, A New Phenanthroindolizidine Alkaloid From Cryptocarya densiflora Blume (Lauraceae) and Molecular Docking Against SARS-CoV-2

Natural Product Communications · 17(8) · ISSN 1934578X

5 citations

2022

A Comprehensive Analysis of Human CYP3A4 Crystal Structures as a Potential Tool for Molecular Docking-Based Site of Metabolism and Enzyme Inhibition Studies

Journal of Computational Biophysics and Chemistry · 21(3) · ISSN 27374165

9 citations

2022

Development and Optimization of Nanoemulsion from Ethanolic Extract of Centella asiatica (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability

Evidence-based Complementary and Alternative Medicine · 2022 · ISSN 1741427X

52 citations

2022

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study

Arabian Journal of Chemistry · 15(1) · ISSN 18785352

9 citations

2022

Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study

Journal of Biomolecular Structure and Dynamics · 40(18) · ISSN 07391102

15 citations

2021

Virtual Screening-Based Identification of Potent DENV-3 RdRp Protease Inhibitors via In-House Usnic Acid Derivative Database

Journal of Computational Biophysics and Chemistry · 20(8) · ISSN 27374165

26 citations

2021

Biocatalytic modifications of ethynodiol diacetate by fungi, anti-proliferative activity, and acetylcholineterase inhibitory of its transformed products

Steroids · 171 · ISSN 0039128X

2 citations

2021

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats

Bioorganic Chemistry · 110 · ISSN 00452068

32 citations

2021

Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids

Molecular Diversity · 25(2) · ISSN 13811991

8 citations

2021

Site of Metabolism (SOM) Predictions for Centella asiatica and Orthosiphon stamineus Marker Compounds with CYP3A4 Using a Molecular Docking Approach

Malaysian Journal of Chemistry · 23(4) · ISSN 15112292

1 citation

2020

Medroxyprogesterone derivatives from microbial transformation as anti-proliferative agents and acetylcholineterase inhibitors (combined in vitro and in silico approaches)

Steroids · 164 · ISSN 0039128X

5 citations

2020

Combining in silico and in vitro studies to evaluate the acetylcholinesterase inhibitory profile of different accessions and the biomarker triterpenes of Centella asiatica

Molecules · 25(15) · ISSN 14203049

20 citations

2020

Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents

Bioorganic Chemistry · 99 · ISSN 00452068

13 citations

2020

Aryl-oxadiazole Schiff bases: Synthesis, α-glucosidase in vitro inhibitory activity and their in silico studies

Arabian Journal of Chemistry · 13(4) · ISSN 18785352

51 citations

2019

Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones

Arabian Journal of Chemistry · 12(8) · ISSN 18785352

21 citations

2019

Synthesis of 3,4,5-trihydroxybenzohydrazone and evaluation of their urease inhibition potential

Arabian Journal of Chemistry · 12(8) · ISSN 18785352

28 citations

2019

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives

Medicinal Chemistry Research · 28(11) · ISSN 10542523

21 citations

2019

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease

Bioorganic Chemistry · 92 · ISSN 00452068

31 citations

2019

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking

Molecules · 24(21) · ISSN 14203049

36 citations

2019

Goniolanceolatins A-H, Cytotoxic Bis-styryllactones from Goniothalamus lanceolatus

Journal of Natural Products · 82(9) · ISSN 01633864

21 citations

2019

Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies

Bioorganic and Medicinal Chemistry · 27(18) · ISSN 09680896

74 citations

2019

Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

Bioorganic and Medicinal Chemistry · 27(14) · ISSN 09680896

15 citations

2019

Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies

Bioorganic Chemistry · 85 · ISSN 00452068

39 citations

2019

α-Glucosidase inhibition and docking studies of 5-deoxyflavonols and dihydroflavonols isolated from abutilon Pakistanicum

Current Organic Chemistry · 23(17) · ISSN 13852728

1 citation

2019

Evaluation of a series of 9,10-anthraquinones as antiplasmodial agents

Letters in Drug Design and Discovery · 16(3) · ISSN 15701808

7 citations

2019

Thiazole based carbohydrazide derivatives as α-amylase inhibitor and their molecular docking study

Heteroatom Chemistry · 2019 · ISSN 10427163

27 citations

2018

Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives

Bioorganic Chemistry · 80 · ISSN 00452068

61 citations

2018

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs

Bioorganic Chemistry · 78 · ISSN 00452068

89 citations

2018

Synthesis, molecular docking study and thymidine phosphorylase inhibitory activity of 3-formylcoumarin derivatives

Bioorganic Chemistry · 78 · ISSN 00452068

19 citations

2018

Rational design of bis-indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase

Bioorganic and Medicinal Chemistry · 26(12) · ISSN 09680896

14 citations

2018

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives

Bioorganic Chemistry · 77 · ISSN 00452068

108 citations

2018

Synthesis: Small library of hybrid scaffolds of benzothiazole having hydrazone and evaluation of their β-glucuronidase activity

Bioorganic Chemistry · 77 · ISSN 00452068

23 citations

2018

Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors

Bioorganic Chemistry · 76 · ISSN 00452068

62 citations

2017

Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study

European Journal of Medicinal Chemistry · 141 · ISSN 02235234

59 citations

2017

3,4-Dimethoxybenzohydrazide derivatives as antiulcer: Molecular modeling and density functional studies

Bioorganic Chemistry · 75 · ISSN 00452068

10 citations

2017

Synthesis and in vitro study of benzofuran hydrazone derivatives as novel alpha-amylase inhibitor

Bioorganic Chemistry · 75 · ISSN 00452068

36 citations

2017

Synthesis of a series of new 6-nitrobenzofuran-2-carbohydrazide derivatives with cytotoxic and antioxidant activity

New Horizons in Translational Medicine · 4(1-4) · ISSN 23075023

4 citations

2017

Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives

Bioorganic Chemistry · 74 · ISSN 00452068

105 citations

2017

Synthesis, α-glucosidase inhibitory activity and in silico study of tris-indole hybrid scaffold with oxadiazole ring: As potential leads for the management of type-II diabetes mellitus

Bioorganic Chemistry · 74 · ISSN 00452068

100 citations

2017

Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies

Bioorganic Chemistry · 74 · ISSN 00452068

82 citations

2017

Synthesis and biological evaluation of indole derivatives as α-amylase inhibitor

Bioorganic Chemistry · 73 · ISSN 00452068

51 citations

2017

Synthesis of indole analogs as potent β-glucuronidase inhibitors

Bioorganic Chemistry · 72 · ISSN 00452068

20 citations

2017

Synthesis of alpha amylase inhibitors based on privileged indole scaffold

Bioorganic Chemistry · 72 · ISSN 00452068

87 citations

2017

Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies

Medicinal Chemistry Research · 26(5) · ISSN 10542523

20 citations

2017

Molecular hybridization conceded exceptionally potent quinolinyl-oxadiazole hybrids through phenyl linked thiosemicarbazide antileishmanial scaffolds: In silico validation and SAR studies

Bioorganic Chemistry · 71 · ISSN 00452068

46 citations

2017

Synthesis and molecular modelling studies of phenyl linked oxadiazole-phenylhydrazone hybrids as potent antileishmanial agents

European Journal of Medicinal Chemistry · 126 · ISSN 02235234

43 citations

2016

In silico binding analysis and SAR elucidations of newly designed benzopyrazine analogs as potent inhibitors of thymidine phosphorylase

Bioorganic Chemistry · 68 · ISSN 00452068

16 citations

2016

Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies

Bioorganic Chemistry · 68 · ISSN 00452068

23 citations

2016

Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs

Bioorganic Chemistry · 68 · ISSN 00452068

66 citations

2016

Synthesis of novel disulfide and sulfone hybrid scaffolds as potent β-glucuronidase inhibitor

Bioorganic Chemistry · 68 · ISSN 00452068

10 citations

2016

Synthesis, molecular docking and α-glucosidase inhibition of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1,3,4-oxadiazoles

Bioorganic Chemistry · 66 · ISSN 00452068

82 citations

2016

Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies

Bioorganic Chemistry · 66 · ISSN 00452068

66 citations

2016

Thiadiazole derivatives as New Class of β-glucuronidase inhibitors

Bioorganic and Medicinal Chemistry · 24(8) · ISSN 09680896

27 citations

2016

Synthesis, α-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles

Bioorganic Chemistry · 65 · ISSN 00452068

59 citations

2016

Synthesis of 6-chloro-2-Aryl-1H-imidazo[4,5-b]pyridine derivatives: Antidiabetic, antioxidant, β-glucuronidase inhibiton and their molecular docking studies

Bioorganic Chemistry · 65 · ISSN 00452068

55 citations

2016

Synthesis, in vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors

Chemical Biology and Drug Design · 87(3) · ISSN 17470277

70 citations

2016

Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential

Medicinal Chemistry Research · 25(2) · ISSN 10542523

27 citations

2016

Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors

Bioorganic and Medicinal Chemistry · 24(16) · ISSN 09680896

58 citations

2016

Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α-glucosidase inhibitory activity, and molecular modeling studies

European Journal of Medicinal Chemistry · 122 · ISSN 02235234

101 citations

2016

Novel thiosemicarbazide-oxadiazole hybrids as unprecedented inhibitors of yeast α-glucosidase and in silico binding analysis

RSC Advances · 6(40) · ISSN 20462069

55 citations

2016

Identification of bisindolylmethane-hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT, and in silico SAR intimations

RSC Advances · 6(4) · ISSN 20462069

30 citations

2016

Synthesis of novel inhibitors of β-glucuronidase based on the benzothiazole skeleton and their molecular docking studies

RSC Advances · 6(4) · ISSN 20462069

46 citations

2015

A review of bisindolylmethane as an important scaffold for drug discovery

Current Medicinal Chemistry · 22(38) · ISSN 09298673

86 citations

2015

Synthesis of novel benzohydrazone-oxadiazole hybrids as β-glucuronidase inhibitors and molecular modeling studies

Bioorganic and Medicinal Chemistry · 23(23) · ISSN 09680896

45 citations

2015

Evaluation of 2-indolcarbohydrazones as potent α-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions

Bioorganic Chemistry · 63 · ISSN 00452068

46 citations

2015

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies

European Journal of Medicinal Chemistry · 105 · ISSN 02235234

137 citations

2015

Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor

Bioorganic Chemistry · 62 · ISSN 00452068

60 citations

2015

Synthesis of new oxadiazole derivatives as α-glucosidase inhibitors

Bioorganic and Medicinal Chemistry · 23(15) · ISSN 09680896

86 citations

2015

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies

Bioorganic and Medicinal Chemistry Letters · 25(16) · ISSN 0960894X

87 citations

2015

Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors

Bioorganic Chemistry · 61 · ISSN 00452068

50 citations

2015

Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies

European Journal of Medicinal Chemistry · 92 · ISSN 02235234

161 citations

2015

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies

Bioorganic and Medicinal Chemistry · 23(22) · ISSN 09680896

35 citations

2015

Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions

MedChemComm · 6(10) · ISSN 20402503

76 citations

2014

4-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzohydrazide

MolBank · 2014(2) · ISSN 14228599

8 citations

2014

Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity

Molecules · 19(8) · ISSN 14203049

96 citations

ChM Dr. Syahrul ImranAbu Bakar

Driven by curiosity, guided by chemistry.

Universiti Teknologi MARA

Anugerah Tuanku Canselor (2016)

Anugerah Perkhidmatan Cemerlang 2020

h-index: 38 (Scopus) · 38 (WoS)

Malaysian Patent (2022)

International Collaborations

Invited Lectures &Professional Service

Invited Lectures

Diabetes Therapeutics: Insights into Alpha-Glucosidase Inhibition

9th International Symposium-Cum-Training Course on Molecular Medicine and Drug Research (MMDR-9)

Journal Peer Review

Registered Copyrights

Computational Design and Molecular Dynamics Simulation of Celastrol-Derived Inhibitors Targeting KRAS G12C Mutant for Cancer Therapy

CYP-DOCKER: Computational Prediction Tool of CYP3A4 Enzyme

Ethynodiol Diacetate Derivatives from Microbial Transformation of Psychrotolerant Fungi as Anti-Proliferative Agents and Acetylcholinesterase Inhibitors (Combined In Vitro and In Silico Approaches)

Publications & Focus Areas

Citation trajectory

Core Collection metrics

Complete Publication List

Therapeutic potential of Ni(II), Pd(II), and Pt(II) coumarin Schiff base complexes for acetylcholinesterase and butyrylcholinesterase inhibition

Theoretical investigation of selective inhibitory activity of chromone-based compounds against monoamine oxidase (MAO)-A and -B

Design, Synthesis, and Computational Studies of Novel N-(Substituted phenyl)-3-(5-((naphthalen-2-yloxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetamides as Potent Acetylcholinesterase Inhibitors

Natural chromones targeting autophagy signalling pathways as potential anticancer interventions: a systematic review

Synthesis and In Vitro Evaluation of Triazole-Based N-(Substituted phenyl)-5-[(benzyl)-4-(phenyl)-4H-1,2,4-triazol-3-ylthio]acetamides as Potent Acetylcholinesterase Inhibitors

Identification of new structure of indol-3-acetyl-arylsulfonohydrazide as potent α-glucosidase and α-amylase inhibitors and molecular docking

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors

Chemical Profile, Physicochemical Properties and Antioxidant Activity of Malaysian Propolis: Insights from Honeybee and Stingless Bee

Synthesis and biological evaluation of novel coumarin derivatives bearing sulfonamide moiety as potent α-glucosidase inhibitors

Molecular networking-based mass spectral identification of Brucea javanica (L.) Merr. metabolites and their selective binding affinities for dengue virus enzymes

New piperidinyl heterocyclic azoles acquired through Li(I)-catalyzed reactions: Anti-enzymatic, ADME and computational studies

Styryllactones in the leaves of Goniothalamus lanceolatus Miq., molecular networking and their anti-dengue activity In vitro and In silico

Synthesis of benzimidazole derivatives and their antiglycation, antioxidant, antiurease and molecular docking study

The role of commonly used transition metals in total synthesis of indole alkaloids

Nanoemulsion of Ethanolic Extract of Centella asiatica (NanoSECA) Ameliorates Learning and Memory Performance by Enhancing Cholinergic Activities, Increasing Antioxidative Levels, and Attenuating Oxidative Stress Markers in Adult Rats

Goniothalamin and Its Analogues as Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme: Molecular Docking, Molecular Dynamics Simulation Studies, and Pharmacokinetics Analysis

New Quinoline Analogues: As Potential Diabetics Inhibitors and Molecular Docking Study

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase

In vitro and in silico assessment of bioactivity properties and pharmacokinetic studies of new 3,5-disubstituted-1,2,4-triazoles

New pyrrolopyridine-based thiazolotriazoles as diabetics inhibitors: enzymatic kinetics and in silico study

Discovering biological efficacy of new thiadiazole as effective inhibitors of urease, glycation, and (DPPH) scavengers: Biochemical and in silico study

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies

Virtual screening of bioactive anti-SARS-CoV natural products and identification of 3β,12-diacetoxyabieta-6,8,11,13-tetraene as a potential inhibitor of SARS-CoV-2 virus and its infection related pathways by MD simulation and network pharmacology

Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation

Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles

Synthesis of ruthenium complexes and their catalytic applications: A review

Computational Screening of Styryl Lactone Compounds Isolated from Goniothalamus Species to Identify Potential Inhibitors for Dengue Virus

Synthesis and Molecular Docking of New Bis-Thiazolidinone-Based Chalcone Analogs as Effective Inhibitors of Acetylcholinesterase and Butyrylcholinesterase

(R)-13aα-Densiindolizidine, A New Phenanthroindolizidine Alkaloid From Cryptocarya densiflora Blume (Lauraceae) and Molecular Docking Against SARS-CoV-2

A Comprehensive Analysis of Human CYP3A4 Crystal Structures as a Potential Tool for Molecular Docking-Based Site of Metabolism and Enzyme Inhibition Studies

Development and Optimization of Nanoemulsion from Ethanolic Extract of Centella asiatica (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study

Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study

Virtual Screening-Based Identification of Potent DENV-3 RdRp Protease Inhibitors via In-House Usnic Acid Derivative Database

Biocatalytic modifications of ethynodiol diacetate by fungi, anti-proliferative activity, and acetylcholineterase inhibitory of its transformed products

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats

Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids

Site of Metabolism (SOM) Predictions for Centella asiatica and Orthosiphon stamineus Marker Compounds with CYP3A4 Using a Molecular Docking Approach

Medroxyprogesterone derivatives from microbial transformation as anti-proliferative agents and acetylcholineterase inhibitors (combined in vitro and in silico approaches)

Combining in silico and in vitro studies to evaluate the acetylcholinesterase inhibitory profile of different accessions and the biomarker triterpenes of Centella asiatica

Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents

Aryl-oxadiazole Schiff bases: Synthesis, α-glucosidase in vitro inhibitory activity and their in silico studies

Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones

Synthesis of 3,4,5-trihydroxybenzohydrazone and evaluation of their urease inhibition potential

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking

Goniolanceolatins A-H, Cytotoxic Bis-styryllactones from Goniothalamus lanceolatus

Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies

Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies

α-Glucosidase inhibition and docking studies of 5-deoxyflavonols and dihydroflavonols isolated from abutilon Pakistanicum

Evaluation of a series of 9,10-anthraquinones as antiplasmodial agents

Thiazole based carbohydrazide derivatives as α-amylase inhibitor and their molecular docking study

Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs

Synthesis, molecular docking study and thymidine phosphorylase inhibitory activity of 3-formylcoumarin derivatives

ChM Dr. Syahrul Imran
Abu Bakar

Driven by curiosity,
guided by chemistry.

Invited Lectures &
Professional Service

Publications &
Focus Areas

Funded Research
Portfolio

Mentoring future
research leaders.